QW, BZ, HJ and YS designed the research study. QW and GX performed the research. QW, JZ and YL analyzed the data. QW and BZ wrote the manuscript. All authors contributed to editorial changes in the manuscript. All authors read and approved the final manuscript. All authors have participated sufficiently in the work and agreed to be accountable for all aspects of the work.

The study was conducted in accordance with the ARRIVE guidelines. The research protocol was approved by the Ethics Committee of Suzhou Hospital of Integrated Traditional Chinese and Western Medicine (Ethic Approval Number: 2023030).

We gratefully acknowledge the assistance and instruction from Dr. Xin Wang and professor Weiwei Tao.

This research was supported by Jiangsu Provincial Association of Chinese Medicine Project No. CYTF2024037. Jiangsu Province Traditional Chinese Medicine Technology Development Project No. MS2023037. Suzhou Applied Basic Research (Medical and Health) Science and Technology Innovation Project No. SYWD2024333. Medical and Health Project on Suzhou Wuzhong District Science and Technology Plan Youth Project No. WZYW2023017. Applied Basic Research on Special Research of Wumenyipai with Shicaixuepai of Suzhou No. SC2023002.

The authors declare no conflict of interest.