HZ and XL performed the experimental study. YZ designed the experimental study. HZ draft the manuscript. All authors contributed to editorial changes in the manuscript. All authors read and approved the final manuscript. All authors have participated sufficiently in the work and agreed to be accountable for all aspects of the work.

The experimental protocols were reviewed and approved by the Animal Ethics Committee of Baotou Central Hospital, China and all procedures were performed under the approved ethical standards. The ethics approval number is [Approval No. 12783948]. All animal testing follows the 3R principle and the ARRIVE guidelines.

Not applicable.

This research received no external funding.

The authors declare no conflicts of interest.

During the preparation of this work, the author used the ChatGPT 4 tool to create Figures 1 and 12. After using this tool, the authors reviewed the content as needed and took full responsibility for the content of the publication.