All authors contributed to the study’s design and preparation and read and approve the final version of the manuscript. HYM: Experimental execution, data collection and analysis, interpretation of results, writing, and manuscript revision. HYW and JX: Animal experimental design. PYC, BZ, and YHZ: Experimental execution, analysis and interpretation of data. YTX and YYL: Specimen acquisition. MXW: Experimental execution, supervision, review and editing, and funding acquisition. All authors contributed to editorial changes in the manuscript. All authors have participated sufficiently in the work and agreed to be accountable for all aspects of the work.
The experimental protocols were approved by the Medical Ethics Review Board of The Tenth Affiliated Hospital, Southern Medical University (Dongguan People’s Hospital) (Approval No. IACUC-AWEC-202410028). All procedures were conducted in accordance with the Regulations on the Administration of Laboratory Animals (China, 2017) and the ARRIVE Guidelines for the ethical treatment and reporting of animal experiments.
The authors sincerely acknowledge the exceptional support and assistance provided by the Central Research Laboratory at The Tenth Affiliated Hospital, Southern Medical University (Dongguan People’s Hospital) in conducting this work. We would also like to express our sincere gratitude to members of the mentor group, Dr. Ning Xiaodong and Dr. Chen Peier, for their invaluable guidance and support throughout the experimental process. Their expertise and encouragement have been instrumental in the successful completion of this study.
This research received no external funding.
The authors declare no conflict of interest.
Supplementary material associated with this article can be found, in the online version, at https://doi.org/10.31083/FBL36781.