YZ, LW: Designed the experiments, Performed the experiments; Collected and analyzed data; Wrote the paper. ZP, WM, TW: technique support. BW, ZY: Designed the experiments and supervision. XL, EC: Designed the experiments, Supervision, and Funding acquisition. All authors contributed to editorial changes in the manuscript. All authors read and approved the final manuscript. All authors have participated sufficiently in the work and agreed to be accountable for all aspects of the work.

This retrospective study was approved by the Institutional Review Board of Peking University Shenzhen Hospital (Approval Number: [2022]No.(164)). Given the retrospective nature of the study and the use of de-identified patient data, the requirement for informed consent was waived by the IRB. The study was conducted in accordance with the ethical standards of the Declaration of Helsinki and its later Follow-up review (Approval Number: [2022]No.(164-Extension 1)). The animal study protocol was approved by the Institutional Review Board (or Ethics Committee) of Peking University Shenzhen Hospital (protocol code 2023-959) for studies involving animals. All animal experiments and operations strictly adhere to the experimental protocols approved by the Laboratory Animal Ethics Committee of Peking University Shenzhen Hospital, as well as national and international laboratory animal welfare guidelines. All experimental animals were euthanized by trained researchers proficient in the cervical dislocation method.

This work was supported by the National Natural Science Foundation of China (82303446), the Shenzhen High-level Hospital Construction Fund and Peking University Shenzhen Hospital Scientific Research Fund (KYQD2023303), GuangDong Basic and Applied Basic Research Foundation (2023A1515220200), Medical Scientific Research Foundation of Guangdong Province of China (A2024351) and the Science and Technology Development Fund Project of Shenzhen (JCYJ20190809095011463).

The authors declare no conflict of interest.